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KMID : 1161920140110010082
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Journal of Medicine and Life Science
2014 Volume.11 No. 1 p.82 ~ p.86
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Magnetic Resonance Imaging Findings in the Brains of Patients with CADASIL
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Lee Jung-Seok
Kang Chul-Hoo
Oh Jung-Hwan
Song Sook-Keun
Choi Jay-Chol
Kang Sa-Yoon
Kang Ji-Hoon
Jeon Bong-Hee
Park Joon-Hyuk
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Abstract
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Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited microangiopathy caused by mutations in the Notch3 gene. Typical findings from magnetic resonance imaging (MRI) include multiple subcortical lacunes, extensive white matter change and multiple cerebral microbleeds (CMBs). Whereas MRI findings are well described in Caucasian patients with CADASIL. There is a paucity of data on Asian patients. We aim to characterized imaging findings in Asian patients with CADASIL. The study population comprised 73 patients who underwent brain MRI between March 2012 and May 2013. T1-weighted image, susceptibility weighted image (SWI), and fluid attenuated inversion recovery (FLAIR) images were analyzed by visual inspection. Clinical information at time of imaging was available for all patients. The mean age of patients (44 men, 29 women) was 63.2±11.8 (SD). In patients with CADASIL, lacunes (76.7%, 56 of 73), CMBs (74%, 54 of 73), and area of white mater hyperintensities (98.6%, 72 of 73) were observed. Lacunes, CMBs, and WMHs were located predominantly in the cortical-subcortical lesion (57.5%, 54.8%, and 98.6%, respectively). These findings suggest that cortical-subcortical area is the most frequently injured area of brain in CADASIL. Further studies are needed to validate our findings.
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KEYWORD
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Cerebral Autosomal-dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL), Lacunes, Cerebral Microbleeds (CMBs), White Matter Change, Cortical-subcortical Area
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